MoAn - Motif Annealer
MoAn is a discriminative pattern finder capable of using a very large
negative set to greatly improve its predictive power. It is capable of
handling sequences that are not repeat masked given that the negative
set is a representative sample of promoters from the organism
examined. It is implemented in C and distributed under the Gnu General
It depends heavily on the Asap C
libraries (Troels Marstrand) and by extension the
library (Giovanni Manzini), but these come bundled with the source so
no additional downloads should be necessary.
Note that I have experienced problems compiling with GCC 4.3. I am
working on this, but in the meantime 4.2 and 4.1 should work. If this
is not your default open the Makefile in the MoAn directory in your
favourite text editor and then change the line:
and make sure you have it installed on your computer. In Ubuntu or Debian this can be done with the command:
sudo apt-get install gcc-4.2
Compiling should simply be a simple matter of unpacking and running make:
tar xvzf moan_current.tar.gz
Paper describing method:
Studies using MoAn:
- Liu, Y., Gao, H., Marstrand, T.T., Strom, A., Valen, E., Sandelin, A., Gustafsson, J.A. and Dahlman-Wright, K.
The genome landscape of ERα- and ERβ-binding DNA regions.
Proceedings of the National Academy of Sciences, 105(7) 2008.